The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes converging in common pathways contribute to the genetic susceptibility in such disorders. Nevertheless, for most autoimmune/autoinflammatory diseases, the HLA genes are by far the strongest risk factors. The basis of some associations has now been elucidated, particularly in those cases in which exogenous factors are involved.

HLA Class I or Class II and Disease Association: Catch the Difference if You Can / Fiorillo, Mt; Paladini, F; Tedeschi, V; Sorrentino, R.. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - STAMPA. - 8:(2017). [10.3389/fimmu.2017.01475]

HLA Class I or Class II and Disease Association: Catch the Difference if You Can

Fiorillo Mt;Paladini F;Tedeschi V;Sorrentino R.
2017

Abstract

The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes converging in common pathways contribute to the genetic susceptibility in such disorders. Nevertheless, for most autoimmune/autoinflammatory diseases, the HLA genes are by far the strongest risk factors. The basis of some associations has now been elucidated, particularly in those cases in which exogenous factors are involved.
2017
HLA class I; HLA class II; autoimmune disease; T cell receptor; self-reactivity
01 Pubblicazione su rivista::01a Articolo in rivista
HLA Class I or Class II and Disease Association: Catch the Difference if You Can / Fiorillo, Mt; Paladini, F; Tedeschi, V; Sorrentino, R.. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - STAMPA. - 8:(2017). [10.3389/fimmu.2017.01475]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1020449
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